The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and somewhat soluble in alcohol. The molecular bodyweight is 406.37. Its molecular formulation is C18H21NO3•H3PO4 • ½ H2O, and it has the following chemical framework.
Promethazine is undoubtedly an H1 receptor blocking agent. In combination with its antihistaminic motion, it offers clinically beneficial sedative and antiemetic results.
Even though the danger of addiction in any individual is mysterious, it could possibly take place in sufferers appropriately prescribed Promethazine with Codeine Oral Answer. Addiction can take place at encouraged dosages and In the event the drug is misused or abused. Threats are elevated in sufferers with a personal or relatives historical past of substance abuse (which includes drug or Liquor abuse or addiction) or mental health issues (eg., key depression).
Use promethazine and codeine as purchased by your health practitioner. Read all details provided to you. Abide by all Guidance intently. Acquire with or without food items. Acquire with foods if it brings about an upset abdomen.
Most MAO inhibitors must also not be taken for 2 months before remedy with this medication. Talk to your medical doctor when to get started on or quit using this medication.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated.
If someone has overdosed and it more info has severe indicators for instance passing out or problems respiratory, contact 911. Normally, phone a poison Command Centre straight away.
3) and Warnings and Safety measures ( five.1) ]. Physical dependence, the problem through which continued administration from the drug is required to stop the looks of the withdrawal syndrome, assumes clinically sizeable proportions only following a number of weeks of continued oral opioid use, Even though some mild diploma of physical dependence might produce right after a couple of days of opioid therapy.
Though it helps many people, this medication provides a risk for abuse and should in some cases cause dependancy. This risk could be increased Should you have a substance use problem (including overuse of or habit to prescription drugs/Alcoholic beverages).
Promethazine with Codeine Oral Solution is indicated for that temporary relief of coughs and higher respiratory indicators connected with allergy or the widespread cold in sufferers 18 yrs of age and older.
Shop at room temperature clear of light-weight and moisture. Never store in the lavatory. Tend not to freeze. Hold all medicines away from children and Animals.
Just take this medication particularly as prescribed to decreased the chance of addiction. Ask your doctor or pharmacist For additional specifics.
Never continue to keep leftover medication. Browse and punctiliously Adhere to the Directions offered with this medicine regarding how to safely and securely get rid of any unused portion. Just one dose may cause death in someone applying this medication accidentally or improperly.
Explain to your doctor If the cough doesn't get well in 5 days. Also, notify your medical doctor In the event your issue receives worse, or In case you have a headache that does not go away, fever, or rash. These could possibly be indications of a serious health care trouble and will be checked by a physician.